Publications
Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale ST, Sagasti A, Modlin RL, Ramakrishnan L. (2017) A macrophage response to Mycobacterium leprae phenolic glycolipid initiates nerve damage in leprosy. Cell. 170(5):973-985. e10. doi: 10.1016/j.cell.2017.07.030
Preview in Trends in Molecular Medicine
Preview in Cell Host & Microbe
Preview in Immunity
Madigan CA, Cameron J, Ramakrishnan L. (2017) A zebrafish model for Mycobacterium leprae granulomatous infection. Journal of Infectious Diseases, doi: 10.1093/infdis/jix329
Inkeles MS, Teles RM, Pouldar D, Andrade PR, Madigan CA, Lopez D, Ambrose M, Noursadeghi M, Sarno EN, Rea TH, Ochoa MT, Iruela-Arispe ML, Ottenhoff TH, Geluk A, Bloom BR, Modlin RL. (2016) Cell-type deconvolution with immune response pathways identifies gene networks of host defense and immunopathology in leprosy. Journal of Clinical Investigation Insight. 1(15):e88843.
Madigan CA, Martinot AJ, Wei J-R, Madduri A, Cheng T-Y, Young DC, Layre E, Murry JP, Rubin EJ, Moody DB. (2015) Mycobactin Synthase K links iron, lipid homeostasis, and virulence in M. tuberculosis. PLoS Pathogens. 11(3):e1004792.
Madigan CA, Cheng TY, Young DC, Layre E, McConnell MJ, Debono CA, Murry JP, Wei JR, Barry CE 3rd, Rodriguez GM, Matsunaga I, Rubin EJ, Moody DB. (2012) Lipidomic discovery of deoxysiderophores reveals a revised pathway of mycobactin biosynthesis in M. tuberculosis. Proceedings of the National Academy of Science. 109(4):1257-62.
Layre E, Sweet L, Hong S, Madigan CA, Desjardins D, Young DC, Cheng TY, Annand JW, Kim K, Shamputa IC, McConnell MJ, Debono CA, Behar SM, Minnaard AJ, Murray M, Barry CE 3rd, Matsunaga I, Moody DB. (2011) A Comparative Lipidomics Platform for Chemotaxonomic Analysis of Mycobacterium tuberculosis. Chemistry & Biology. 18(12): 1537-49.
Huang S, Cheng TY, Young DC, Layre E, Madigan CA, Shires J, Cerundolo V, Altman JD, Moody DB. (2011) Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system. Proceedings of the National Academy of Science 108(48): 19335-40.
Molofsky AB, Byrne BG, Whitfield NN, Madigan CA, Fuse ET, Tateda K, Swanson MS. (2006) Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. Journal of Experimental Medicine. 203(4): 1093-104.